802D: 渗透性纤维装置

        Aurora Scientific 802D渗透纤维测试仪器是为方便使用而设计的，研究人员只需按下一个按钮就能自动测量不同pCa下的纤维动态。

       八孔槽板是耐腐蚀的，允许研究人员测试多种溶液，而不需要清空和重新填充槽。浴槽1是最大的浴槽，便于纤维的附着，并在两侧包括直角棱镜，用于精确测量纤维的横截面。

       每台仪器都包含XYZ测微台，内置Aurora Scientific高速长度控制器（315C, 322C）和力传感器（400A系列）的支架。利用基于微处理器的控制器和我们的600A软件，研究人员可以定义纤维在指定的时间点放在哪个浴槽中。

      重要的是，移动浴槽板而不是移动光纤可以确保更准确地测量力，减少组织损伤的机会。位置传感器确保浴槽放置的准确性优于+/- 0.025毫米。

● 8孔温控水浴板（0-40°C，+/-0.1°C内）。

● 只需按下一个按钮，就可以从任何一个浴槽自动转到另一个浴槽。

● 浴槽与浴槽之间的快速转换(1.2s)

● 包括XYZ微操作手

● 可选择120微升或160微升的浴槽容量

● 浴槽1的设计便于安装样品光纤，具有直角棱镜，可观察到光纤的轮廓

● 玻璃底浴槽可在解剖镜或倒置显微镜下观察样品

● 基于微处理器的运动控制器和TEC控制器

● 整体采用耐腐蚀材料

• Larkin, Lisa M. et al “Weakness of whole muscles in mice deficient in Cu, Zn superoxide dismutase is not explained by defects at the level of the contractile apparatus.” Age (2013) DOI: 10.1007/s11357-012-9441-7

• van der Pijl et al. “Titin-based mechanosensing modulates muscle hypertrophy” Journal of Cachexia, Sarcopenia and Muscle (2018) DOI: 10.1002/jcsm.12319

• Fukutani et al. “Influence of residual force enhancement and elongation of attached cross-bridges on stretch-shortening cycle in skinned muscle fibers” Physiological Reports (2017) DOI: 10.14814/phy2.13477

• Zhang, Tan et al. “Human slow troponin T (TNNT1) pre-mRNA alternative splicing is an indicator of skeletal muscle response to resistance exercise in older adults” The Journals of Gerontology: Series A, Biological Sciences and Medical Sciences (2014) DOI: 10.1093/gerona/glt204

• Manders, Emmy et al. “Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction.” American Journal of Physiology-Lung Cellular and Molecular Physiology (2012) DOI: 10.1152/ajplung.00135.2012

• Klaiman, Jordan M. “Cold acclimation increases cardiac myofilament function and ventricular pressure generation in trout.” The Journal of Experimental Biology (2014) DOI: 10.1242/jeb.109041

• Lee, Eun-Jeong, et al. “Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.” Archives of Biochemistry and Biophysics (2013) DOI: 10.1016/j.abb.2012.12.004

• Gineste, Charlotte, et al. “Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy” PLoS ONE (2014) DOI: 10.1371/journal.pone.0109066

• Bezold, Kristina L. et al. “A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin” Journal of Biological Chemistry (2013) DOI: 10.1074/jbc.M113.474346